InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dapk2

Summary

InnateDB Gene

IDBG-178934.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dapk2

Gene Name

death-associated protein kinase 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032380

Encoded Proteins

IDBP-178936

death-associated protein kinase 2

IDBP-540157

death-associated protein kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000035664:
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:66158223-66272242

Strand

Forward strand

Band

Transcripts

ENSMUST00000034944	ENSMUSP00000034944
ENSMUST00000129442
ENSMUST00000132987	ENSMUSP00000117134
ENSMUST00000129778

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0043276	anoikis
GO:1900119	positive regulation of execution phase of apoptosis
GO:2001242	regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0031410	cytoplasmic vesicle
GO:0034423	autophagic vacuole lumen

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000035664

View Gene Order

Pathways

NETPATH

REACTOME

REACT_258521

Apoptosis pathway

REACT_252543

Role of DCC in regulating apoptosis pathway

REACT_227606

Regulation of Apoptosis pathway

KEGG

mmu05219

Bladder cancer pathway

mmu05200

Pathways in cancer pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22128

Role of DCC in regulating apoptosis pathway

REACT_578

Apoptosis pathway

REACT_13648

Regulation of Apoptosis pathway

KEGG

hsa05219

Bladder cancer pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.335252 Mm.408195

RefSeq

NM_010019 XM_006510811

OMIM

CCDS

CCDS23303

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas