InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nrip1

Summary

InnateDB Protein

IDBP-171523.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrip1

Protein Name

nuclear receptor interacting protein 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051726

InnateDB Gene

IDBG-171519 (Nrip1)

Protein Structure

UniProt Annotation

Function

Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. {ECO:0000269PubMed:10531331, ECO:0000269PubMed:11100122, ECO:0000269PubMed:15130509, ECO:0000269PubMed:15155905, ECO:0000269PubMed:15919748, ECO:0000269PubMed:9774688}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15879431}.

Disease Associations

Tissue Specificity

Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments. {ECO:0000269PubMed:11100122, ECO:0000269PubMed:15155905, ECO:0000269PubMed:9774688}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	18 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030331	estrogen receptor binding
GO:0035257	nuclear hormone receptor binding
GO:0035259	glucocorticoid receptor binding
GO:0042826	histone deacetylase binding
GO:0042974	retinoic acid receptor binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001543	ovarian follicle rupture
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0019915	lipid storage
GO:0030728	ovulation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter