Version 5.4
Mus musculus Gene: Nrip1
Summary
InnateDB Gene IDBG-171519.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nrip1
Gene Name nuclear receptor interacting protein 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000048490
Encoded Proteins
IDBP-171523
nuclear receptor interacting protein 1
IDBP-400955
nuclear receptor interacting protein 1
IDBP-533269
nuclear receptor interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22388040
NF-κB-mediated degradation of the coactivator NRIP1 (RIP140) regulates inflammatory responses and contributes to endotoxin tolerance.
PMID 22388040
Nrip1 is degraded by the NF-kB pathway to inactivate inflammatory gene expression and promotes endotoxin tolerance.
PMID 26228026
Nrip1 plays dual roles in regulating the M1-M2 phenotype switch in macrophages: in the nucleus as an M1 enhancer and in the cytosol as an M2 suppressor.
InnateDB Annotation from Orthologs
Summary
PMID 22388040
[Homo sapiens] NF-κB-mediated degradation of the coactivator NRIP1 (RIP140) regulates inflammatory responses and contributes to endotoxin tolerance. (Demonstrated in mice)
PMID 22388040
[Homo sapiens] NRIP1 is degraded by the NF-kB pathway to inactivate inflammatory gene expression and promotes endotoxin tolerance. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180530:
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:76287400-76373827
Strand Reverse strand
Band C3.1
Transcripts
ENSMUST00000054178 ENSMUSP00000051726
ENSMUST00000121927 ENSMUSP00000112959
ENSMUST00000140483 ENSMUSP00000123638
ENSMUST00000141182
ENSMUST00000128871
ENSMUST00000145649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 18 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030331 estrogen receptor binding
GO:0035257 nuclear hormone receptor binding
GO:0035259 glucocorticoid receptor binding
GO:0042826 histone deacetylase binding
GO:0042974 retinoic acid receptor binding
GO:0046965 retinoid X receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001543 ovarian follicle rupture
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0019915 lipid storage
GO:0030728 ovulation
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000180530
View Gene Order
ENSBTAG00000047293
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
ar_pathway
Coregulation of Androgen receptor activity
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.409338 Mm.449579 Mm.453339 Mm.455873 Mm.74711
RefSeq NM_173440 XM_006523050 XM_006523051 XM_006523052 XM_006523053 XM_006523054
OMIM
CCDS CCDS28274
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca