InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Evl

Summary

InnateDB Protein

IDBP-170760.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Evl

Protein Name

Ena-vasodilator stimulated phosphoprotein

Synonyms

AI528774;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076916

InnateDB Gene

IDBG-170758 (Evl)

Protein Structure

UniProt Annotation

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. {ECO:0000269PubMed:10087267, ECO:0000269PubMed:10945997}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:10945997}. Cell projection, lamellipodium {ECO:0000269PubMed:10945997}. Note=Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes.

Disease Associations

Tissue Specificity

Highest expression in thymus and spleen (at protein level). Low levels in placenta, ovary, testis, fat and lung (at protein level). Isoform 1 and isoform 2 are expressed in cortical neurons and glial cells. {ECO:0000269PubMed:10069337, ECO:0000269PubMed:10945997}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0007411	axon guidance
GO:0008154	actin polymerization or depolymerization
GO:0030048	actin filament-based movement
GO:0030168	platelet activation
GO:0030838	positive regulation of actin filament polymerization
GO:0045010	actin nucleation
GO:0051016	barbed-end actin filament capping
GO:0051289	protein homotetramerization