Version 5.4
Mus musculus Protein: Igfbp1
Summary
InnateDB Protein IDBP-148837.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Igfbp1
Protein Name insulin-like growth factor binding protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000020704
InnateDB Gene IDBG-148835 (Igfbp1)
Protein Structure
UniProt Annotation
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005520 insulin-like growth factor binding
Biological Process
GO:0001558 regulation of cell growth
GO:0008286 insulin receptor signaling pathway
GO:0030307 positive regulation of cell growth
GO:0042246 tissue regeneration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:96436
InterPro IPR000716 Thyroglobulin type-1
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
IPR022322 Insulin-like growth factor-binding protein 1
PFAM PF00086
PF00219
PRINTS PR01976
PR01977
PIRSF
SMART SM00211
SM00121
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P47876
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 16006
UniGene Mm.21300
RefSeq NP_032367
MGI ID
MGI Symbol Igfbp1
OMIM
CCDS CCDS24427
HPRD
IMGT
EMBL AL607124 CH466574 X67493 X81579
GenPept CAA47832 CAA57269 CAI24501 EDL40608

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca