InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ash2l

Summary

InnateDB Protein

IDBP-144564.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ash2l

Protein Name

ash2 (absent, small, or homeotic)-like (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070957

InnateDB Gene

IDBG-144562 (Ash2l)

Protein Structure

UniProt Annotation

Function

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with abundant expression in the heart, skeletal muscle and kidney. Low expression is seen in spleen, lung and testis. {ECO:0000269PubMed:10393421}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0008284	positive regulation of cell proliferation
GO:0043627	response to estrogen
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051568	histone H3-K4 methylation

Cellular Component

GO:0005634	nucleus
GO:0035097	histone methyltransferase complex
GO:0048188	Set1C/COMPASS complex
GO:0071339	MLL1 complex

Protein Structure and Domains

PDB ID

MGI:1344416

InterPro

IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup

PFAM

PF00622

PRINTS

PIRSF

SMART

SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91X20