Version 5.4
Mus musculus Gene: Ash2l
Summary
InnateDB Gene IDBG-144562.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ash2l
Gene Name ash2 (absent, small, or homeotic)-like (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000031575
Encoded Proteins
IDBP-144564
ash2 (absent, small, or homeotic)-like (Drosophila)
IDBP-259885
ash2 (absent, small, or homeotic)-like (Drosophila)
IDBP-259887
ash2 (absent, small, or homeotic)-like (Drosophila)
IDBP-259889
ash2 (absent, small, or homeotic)-like (Drosophila)
IDBP-536877
ash2 (absent, small, or homeotic)-like (Drosophila)
IDBP-532079
ash2 (absent, small, or homeotic)-like (Drosophila)
IDBP-627248
ash2 (absent, small, or homeotic)-like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129691:
Gene Information
Type Protein coding
Genomic Location Chromosome 8:25816191-25847694
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000068892 ENSMUSP00000070957
ENSMUST00000110610 ENSMUSP00000106240
ENSMUST00000110609 ENSMUSP00000106239
ENSMUST00000110608 ENSMUSP00000106238
ENSMUST00000139946 ENSMUSP00000118346
ENSMUST00000151856 ENSMUSP00000117488
ENSMUST00000149550
ENSMUST00000142358
ENSMUST00000156759
ENSMUST00000166078 ENSMUSP00000132546
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 67 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0008284 positive regulation of cell proliferation
GO:0043627 response to estrogen
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
GO:0071339 MLL1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129691
View Gene Order
ENSBTAG00000000978
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_219771
deactivation of the beta-catenin transactivating complex pathway
REACT_216539
formation of the beta-catenin:TCF transactivating complex pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RI55
UniProt Splice Variant
Entrez Gene 23808
UniGene Mm.405738 Mm.437774
RefSeq NM_001080793 NM_001286207 NM_011791
OMIM
CCDS CCDS40307 CCDS40308
HPRD
IMGT
MGI ID MGI:1344416
MGI Symbol Ash2l
EMBL AC122752
GenPept
RNA Seq Atlas 23808

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca