Version 5.4
Mus musculus Protein: Eif4enif1
Summary
InnateDB Protein IDBP-138654.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4enif1
Protein Name eukaryotic translation initiation factor 4E nuclear import factor 1
Synonyms 2610509L04Rik; A930019J01Rik; AA410001; AU021239; Clast4; D11Ertd166e;
Species Mus musculus
Ensembl Protein ENSMUSP00000020734
InnateDB Gene IDBG-138652 (Eif4enif1)
Protein Structure
UniProt Annotation
Function Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 10 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016605 PML body
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:1921453
InterPro IPR018862 Eukaryotic translation initiation factor 4E transporter
PFAM PF10477
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EST3
PhosphoSite PhosphoSite-Q9EST3
TrEMBL Q5NBZ7
UniProt Splice Variant
Entrez Gene 74203
UniGene Mm.328437
RefSeq NP_001160020
MGI ID
MGI Symbol Eif4enif1
OMIM
CCDS CCDS48739
HPRD
IMGT
EMBL AB031388 AK012082 AL671968 BC033410 CH466574
GenPept AAH33410 BAB11963 BAB28016 CAI35201 EDL40398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca