InnateDB Protein
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IDBP-12245.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAS2R1
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Protein Name
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taste receptor, type 2, member 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000371932
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InnateDB Gene
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IDBG-12243 (TAS2R1)
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Protein Structure
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Function |
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0001580
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detection of chemical stimulus involved in sensory perception of bitter taste
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GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0007635
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chemosensory behavior
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GO:0050909
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sensory perception of taste
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Cellular Component |
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PDB ID |
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InterPro |
IPR007960
Mammalian taste receptor
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PFAM |
PF05296
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NYW7
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PhosphoSite |
PhosphoSite-Q9NYW7
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TrEMBL |
U3KQT0
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UniProt Splice Variant |
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Entrez Gene |
50834
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UniGene |
Hs.567492
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RefSeq |
NP_062545
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HUGO |
HGNC:14909
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OMIM |
604796
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CCDS |
CCDS3876
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HPRD |
07267
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IMGT |
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EMBL |
AB198983
AB198985
AC026787
AC034214
AF227129
AY724812
BC101729
BC101731
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GenPept |
AAF43902
AAI01730
AAI01732
AAU21051
BAD97889
BAD97891
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