Homo sapiens Gene: TAB1

Summary
InnateDB Gene IDBG-8281.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol TAB1
Gene Name TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms 3'-Tab1; MAP3K7IP1
Species Homo sapiens
Ensembl Gene ENSG00000100324
Encoded Proteins
IDBP-8283 TGF-beta activated kinase 1/MAP3K7 binding protein 1
IDBP-8285 TGF-beta activated kinase 1/MAP3K7 binding protein 1
InnateDB Annotation
Summary
PMID 15590691 MAP3K7IP1 induces MAP3K7 autophosphorylation/activation and inhibits MAP3K7 interaction with the IKK signalosome.
PMID 8638164 MAP3K7IP1 functions as an activator of the MAP3K7 (TAK1) in TGF-beta signal transduction.
PMID 14592977 MAP3K&IP1 participates in a SAPK2a/p38alpha-mediated feedback control of MAP3K7, which not only limits the activation of SAPK2a/p38alpha but synchronizes its activity with other signalling pathways that lie downstream of MAP3K7 (JNK and IKK).
PMID 16407200 MAP3K7IP1 modulates intracellular localization of MAPK14 (p38) and downstream signalling.
Entrez Gene
Summary The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22: 39795746-39833065
Strand Forward strand
Band q13.1
Transcripts
ENST00000216160  ENSP00000216160
ENST00000331454  ENSP00000333049
ENST00000473613 
ENST00000461775 
ENST00000490819 
ENST00000473491 
ENST00000488859 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 110 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 110 [view]
Protein‑Protein  109
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 1
[view]
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 5 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0019209 kinase activator activity
Biological Process
GO:0000185 activation of MAPKKK activity
GO:0000187 activation of MAPK activity
GO:0001701 in utero embryonic development
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003007 heart morphogenesis
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB cascade
GO:0007254 JNK cascade
GO:0008063 Toll signaling pathway
GO:0030324 lung development
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000022414 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000019828 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
NetPath_13 IL1 pathway
NetPath_21 RANKL pathway
NetPath_7 TGF_beta_Receptor pathway
NetPath_9 TNFalpha pathway
REACTOME
REACT_25380 IRAK2 mediated activation of TAK1 complex
REACT_25018 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
REACT_22442 Interleukin-1 signaling
REACT_75776 NOD1/2 Signaling Pathway
REACT_25351 TRAF6 mediated induction of TAK1 complex
KEGG
hsa05140  Leishmaniasis
hsa04010  MAPK signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04380  Osteoclast differentiation
hsa04620  Toll-like receptor signaling pathway
hsa05145  Toxoplasmosis
INOH
INOH website B cell receptor signaling pathway
INOH website BMP2 signaling pathway (through TAK1) - BMP2 signaling (through TAK1)
INOH website IKK activation signaling (through PKC beta and CARMA1:BCL10:MALT1) - B cell receptor signaling
INOH website IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1) - CD4 T cell receptor signaling
INOH website IKK activation signaling (through PKC theta and CARMA1:BCL10:MALT1) - CD4 T cell receptor signaling (NF-kB cascade)
INOH website IL-1 signaling pathway (through p38 cascade)
INOH website IL-1 signaling (through IKK-NFkB cascade) (canonical) - IL-1 signaling pathway (through NF-kappaB)
INOH website IL-1 signaling (through JNK cascade) (canonical) - IL-1 signaling pathway (through JNK cascade)
INOH website T cell receptor signaling (PLC gamma, PKC, Ras and IKK-NF-kappaB cascade) - CD4 T cell receptor signaling (NF-kB cascade)
INOH website T cell receptor signaling pathway - CD4 T cell receptor signaling
INOH website TGF beta signaling pathway (through TAK1) - TGF-beta signaling (through TAK1)
INOH website Toll-like receptor signaling pathway (p38 cascade)
INOH website Toll-like receptor signaling pathway (through JNK cascade) (Canonical)
INOH website Toll-like receptor signaling pathway (through LPS, TLR4, MyD88, IRAK, TAK1 and IKK-NF-kappaB cascade) (Canonical) - Toll-like receptor signaling pathway (trough NF-kappaB)
PID BIOCARTA
100097 Nf-kb signaling pathway [Biocarta view]
100132 Signal transduction through il1r [Biocarta view]
100017 Tgf beta signaling pathway [Biocarta view]
100013 Toll-like receptor pathway [Biocarta view]
100002 Wnt signaling pathway [Biocarta view]
PID NCI
il1pathway IL1-mediated signaling events
Interleukin_1_signaling Interleukin-1 signaling
ps1pathway Presenilin action in Notch and Wnt signaling
p38alphabetapathway Regulation of p38-alpha and p38-beta
TRAF6_Mediated_Induction_of_the_antiviral_cytokine_IFN_alpha_beta_cascade TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade
Cross-References
SwissProt Q15750 
TrEMBL A8K6K3 B7Z9N9
UniProt Splice Variant
Entrez Gene 10454 
UniGene Hs.507681 Hs.614431
RefSeq NM_006116  NM_153497 
HUGO 18157 
OMIM 602615
CCDS CCDS13992  CCDS13993 
HPRD 04012
IMGT
EMBL AF425640 AK291668 AK312456 AK316004 AL022312 BC050554 CH471095 DQ314876 U49928 Z83845
GenPept AAC12660  AAH50554  AAN32760  ABC40735  BAF84357  BAG35363  BAH14375  CAB55304  CAQ07045  EAW60326  EAW60330 
ImmGen TAB1 (murine) 
RNA Seq Atlas 10454