InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAB1

Summary

InnateDB Gene

IDBG-8281.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAB1

Gene Name

TGF-beta activated kinase 1/MAP3K7 binding protein 1

Synonyms

3\'-Tab1; MAP3K7IP1

Species

Homo sapiens

Ensembl Gene

ENSG00000100324

Encoded Proteins

IDBP-8283

TGF-beta activated kinase 1/MAP3K7 binding protein 1

IDBP-8285

TGF-beta activated kinase 1/MAP3K7 binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15590691

MAP3K7IP1 induces MAP3K7 autophosphorylation/activation and inhibits MAP3K7 interaction with the IKK signalosome.

PMID 8638164

MAP3K7IP1 functions as an activator of the MAP3K7 (TAK1) in TGF-beta signal transduction.

PMID 14592977

MAP3K&IP1 participates in a SAPK2a/p38alpha-mediated feedback control of MAP3K7, which not only limits the activation of SAPK2a/p38alpha but synchronizes its activity with other signalling pathways that lie downstream of MAP3K7 (JNK and IKK).

PMID 16407200

MAP3K7IP1 modulates intracellular localization of MAPK14 (p38) and downstream signalling.

Entrez Gene

Summary

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:39399741-39437060

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000216160	ENSP00000216160
ENST00000331454	ENSP00000333049
ENST00000473613
ENST00000461775
ENST00000490819
ENST00000473491
ENST00000488859

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	157 [view]
Protein-Protein	156 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0019209	kinase activator activity
GO:0032403	protein complex binding
GO:0048273	mitogen-activated protein kinase p38 binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0000187	activation of MAPK activity
GO:0001701	in utero embryonic development
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0003007	heart morphogenesis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007254	JNK cascade
GO:0030324	lung development
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051403	stress-activated MAPK cascade
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022414

View Gene Order

ENSBTAG00000019828

Not yet available

Pathways

NETPATH

NetPath_7

TGF_beta_Receptor pathway

NetPath_9

TNFalpha pathway

NetPath_13

IL1 pathway

NetPath_21

RANKL pathway

REACTOME

REACT_21368

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway

REACT_21399

activated TAK1 mediates p38 MAPK activation pathway

REACT_25351

TRAF6 mediated induction of TAK1 complex pathway

REACT_21281

TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway

REACT_6809

MyD88-independent cascade pathway

REACT_6783

Toll Like Receptor 3 (TLR3) Cascade pathway

REACT_25380

IRAK2 mediated activation of TAK1 complex pathway

REACT_6788

MyD88:Mal cascade initiated on plasma membrane pathway

REACT_8005

Toll Like Receptor TLR1:TLR2 Cascade pathway

REACT_8006

Toll Like Receptor TLR6:TLR2 Cascade pathway

REACT_25018

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway

REACT_25024

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway

REACT_25222

MyD88 dependent cascade initiated on endosome pathway

REACT_9047

Toll Like Receptor 9 (TLR9) Cascade pathway

REACT_27215

MyD88 cascade initiated on plasma membrane pathway

REACT_9027

Toll Like Receptor 10 (TLR10) Cascade pathway

REACT_6894

Toll Like Receptor 4 (TLR4) Cascade pathway

REACT_9061

Toll Like Receptor 5 (TLR5) Cascade pathway

REACT_75776

NOD1/2 Signaling Pathway pathway

REACT_22442

Interleukin-1 signaling pathway

REACT_163994

FCERI mediated NF-kB activation pathway

REACT_9020

Toll Like Receptor 7/8 (TLR7/8) Cascade pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_6802

Innate Immune System pathway

REACT_7980

Toll Like Receptor 2 (TLR2) Cascade pathway

REACT_6966

Toll-Like Receptors Cascades pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_21308

MAP kinase activation in TLR cascade pathway

REACT_75913

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway

REACT_6900

Immune System pathway

REACT_22232

Signaling by Interleukins pathway

REACT_6890

Activated TLR4 signalling pathway

REACT_25281

TRIF-mediated TLR3/TLR4 signaling pathway

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04620

Toll-like receptor signaling pathway pathway

hsa04621

NOD-like receptor signaling pathway pathway

hsa05140

Leishmaniasis pathway

hsa04380

Osteoclast differentiation pathway

hsa05145

Toxoplasmosis pathway

INOH

INOH website

IL-1 signaling pathway pathway

INOH website

Toll-like receptor signaling pathway pathway

INOH website

TGF-beta signaling pathway

INOH website

BMP2 signaling pathway

PID NCI

ps1pathway

Presenilin action in Notch and Wnt signaling

il1pathway

IL1-mediated signaling events

p38alphabetapathway

Regulation of p38-alpha and p38-beta

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.507681 Hs.614431

RefSeq

NM_006116 NM_153497

HUGO

OMIM

CCDS

CCDS13992 CCDS13993

HPRD

04012

IMGT

EMBL

GenPept

RNA Seq Atlas