InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAB1

Summary

InnateDB Protein

IDBP-8283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAB1

Protein Name

TGF-beta activated kinase 1/MAP3K7 binding protein 1

Synonyms

3\'-Tab1; MAP3K7IP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000216160

InnateDB Gene

IDBG-8281 (TAB1)

Protein Structure

UniProt Annotation

Function

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	157 [view]
Protein-Protein	156 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0019209	kinase activator activity
GO:0032403	protein complex binding
GO:0048273	mitogen-activated protein kinase p38 binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0000187	activation of MAPK activity
GO:0001701	in utero embryonic development
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0003007	heart morphogenesis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007254	JNK cascade
GO:0030324	lung development
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051403	stress-activated MAPK cascade
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway