Version 5.4
| Homo sapiens Gene: TIMP3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-5236.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TIMP3 | ||||||||||||||||||
| Gene Name | TIMP metallopeptidase inhibitor 3 | ||||||||||||||||||
| Synonyms | HSMRK222; K222; K222TA2; SFD | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000100234 | ||||||||||||||||||
| Encoded Proteins |
TIMP metallopeptidase inhibitor 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008] This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby\'s fundus dystrophy. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 22:32801701-32863043 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q12.3 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P35625 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 7078 | ||||||||||||||||||
| UniGene | Hs.644633 Hs.686770 Hs.714083 Hs.714168 | ||||||||||||||||||
| RefSeq | NM_000362 | ||||||||||||||||||
| HUGO | HGNC:11822 | ||||||||||||||||||
| OMIM | 188826 | ||||||||||||||||||
| CCDS | CCDS13911 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AK314871 AL023282 BC014277 BT006848 CH471095 CR456593 L15078 S78453 U02571 U14394 U33110 U33111 U33112 U33113 U33114 U38952 U38953 U38954 U38955 U67195 X76227 Z30183 Z98256 | ||||||||||||||||||
| GenPept | AAA17672 AAA21815 AAB07547 AAB17602 AAB34532 AAB60373 AAC50393 AAH14277 AAP35494 BAG37386 CAA53813 CAA82918 CAG30479 CAI17996 CAI20115 EAW60038 | ||||||||||||||||||
| RNA Seq Atlas | 7078 | ||||||||||||||||||