Version 5.4
Homo sapiens Gene: SPECC1L
Summary
InnateDB Gene IDBG-2815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPECC1L
Gene Name sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms CYTSA; OBLFC1
Species Homo sapiens
Ensembl Gene ENSG00000100014
Encoded Proteins
IDBP-2817
sperm antigen with calponin homology and coiled-coil domains 1-like
IDBP-367378
sperm antigen with calponin homology and coiled-coil domains 1-like
IDBP-367382
sperm antigen with calponin homology and coiled-coil domains 1-like
IDBP-367396
sperm antigen with calponin homology and coiled-coil domains 1-like
IDBP-592419
sperm antigen with calponin homology and coiled-coil domains 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:24270817-24417740
Strand Forward strand
Band q11.23
Transcripts
ENST00000314328 ENSP00000325785
ENST00000437398 ENSP00000393363
ENST00000421374 ENSP00000405671
ENST00000416735
ENST00000440893 ENSP00000414354
ENST00000472799
ENST00000541492 ENSP00000439633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0007026 negative regulation of microtubule depolymerization
GO:0007049 cell cycle
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0030835 negative regulation of actin filament depolymerization
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005921 gap junction
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0031941 filamentous actin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033444
View Gene Order
ENSBTAG00000021656
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.474384 Hs.682038
RefSeq NM_001145468 NM_001254732 NM_001254733 NM_015330
HUGO
OMIM
CCDS CCDS33619 CCDS58797
HPRD 11080
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca