InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPECC1L

Summary

InnateDB Protein

IDBP-2817.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPECC1L

Protein Name

sperm antigen with calponin homology and coiled-coil domains 1-like

Synonyms

CYTSA; OBLFC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000325785

InnateDB Gene

IDBG-2815 (SPECC1L)

Protein Structure

UniProt Annotation

Function

Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration. {ECO:0000269PubMed:21703590}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:21703590}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:21703590}. Cell junction, gap junction {ECO:0000269PubMed:21703590}. Note=Colocalizes with acetylated alpha-tubulin, gamma-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center.

Disease Associations

Facial clefting, oblique, 1 (OBLFC1) [MIM:600251]: A rare form of facial clefting. A facial cleft is any of the fissures between the embryonic prominences that normally unite to form the face. {ECO:0000269PubMed:21703590}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0007026	negative regulation of microtubule depolymerization
GO:0007049	cell cycle
GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0030835	negative regulation of actin filament depolymerization
GO:0051301	cell division

Cellular Component

GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005921	gap junction
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0031941	filamentous actin

Protein Structure and Domains

PDB ID

InterPro

IPR001715 Calponin homology domain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00307
PF00010
PF11971

PRINTS

PIRSF

SMART

SM00033
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q69YQ0