InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRPM5

Summary

InnateDB Gene

IDBG-22743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPM5

Gene Name

transient receptor potential cation channel, subfamily M, member 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000070985

Encoded Proteins

IDBP-22747

transient receptor potential cation channel, subfamily M, member 5

IDBP-597073

transient receptor potential cation channel, subfamily M, member 5

IDBP-598072

transient receptor potential cation channel, subfamily M, member 5

IDBP-597211

transient receptor potential cation channel, subfamily M, member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26847546

[Mus musculus] Tuft cells express Il25 and elicit group 2 innate lymphoid cells in a Trpm5-dependent manner in response to parasite colonization.

Entrez Gene

Summary

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:2404515-2423045

Strand

Reverse strand

Band

p15.5

Transcripts

ENST00000155858	ENSP00000155858
ENST00000533881	ENSP00000434383
ENST00000533060	ENSP00000434121
ENST00000528453	ENSP00000436809

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005267	potassium channel activity
GO:0005272	sodium channel activity

Biological Process

GO:0006812	cation transport
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000009246

View Gene Order

ENSBTAG00000046662

Not yet available

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

REACT_169333

TRP channels pathway

KEGG

hsa04742

Taste transduction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.272287

RefSeq

NM_014555 XM_005252882

HUGO

OMIM

CCDS

CCDS31340

HPRD

16064

IMGT

EMBL

GenPept

RNA Seq Atlas