InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPM5

Summary

InnateDB Protein

IDBP-22747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPM5

Protein Name

transient receptor potential cation channel, subfamily M, member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000155858

InnateDB Gene

IDBG-22743 (TRPM5)

Protein Structure

UniProt Annotation

Function

Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage- dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals. {ECO:0000269PubMed:14634208}.

Subcellular Localization

Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250UniProtKB:Q8TD43, ECO:0000255}.

Disease Associations

Tissue Specificity

Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression. {ECO:0000269PubMed:10607831}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005267	potassium channel activity
GO:0005272	sodium channel activity

Biological Process

GO:0006812	cation transport
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071805	potassium ion transmembrane transport