Version 5.4
Homo sapiens Gene: UBA6
Summary
InnateDB Gene IDBG-21066.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBA6
Gene Name ubiquitin-like modifier activating enzyme 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000033178
Encoded Proteins
IDBP-21068
ubiquitin-like modifier activating enzyme 6
IDBP-369127
ubiquitin-like modifier activating enzyme 6
IDBP-480286
ubiquitin-like modifier activating enzyme 6
IDBP-478274
ubiquitin-like modifier activating enzyme 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:67612652-67701179
Strand Reverse strand
Band q13.2
Transcripts
ENST00000322244 ENSP00000313454
ENST00000420827 ENSP00000399234
ENST00000429659
ENST00000514261 ENSP00000425091
ENST00000505673 ENSP00000421984
ENST00000506571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008641 small protein activating enzyme activity
GO:0016874 ligase activity
GO:0019780 FAT10 activating enzyme activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035898
View Gene Order
ENSBTAG00000006837
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt A0AVT1
TrEMBL
UniProt Splice Variant
Entrez Gene 55236
UniGene Hs.630248 Hs.634362 Hs.637754 Hs.743227
RefSeq NM_018227 XM_006714253
HUGO HGNC:25581
OMIM 611361
CCDS CCDS3516
HPRD 13341
IMGT
EMBL AB014773 AC079880 AC096720 AK001670 AK094969 AK314371 AL832015 AL832458 AY359880 BC031637 BC126484 BC126486 EF623993
GenPept AAH31637 AAI26485 AAI26487 AAQ63403 AAY40999 ABR25253 BAA91824 BAB19785 BAC04463 BAG37000 CAD89908 CAD89959
RNA Seq Atlas 55236

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca