InnateDB Protein
|
IDBP-369127.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
UBA6
|
Protein Name
|
ubiquitin-like modifier activating enzyme 6
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000399234
|
InnateDB Gene
|
IDBG-21066 (UBA6)
|
Protein Structure
|
|
Function |
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269PubMed:15202508, ECO:0000269PubMed:17597759, ECO:0000269PubMed:17889673}.
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. {ECO:0000269PubMed:15202508, ECO:0000269PubMed:17597759}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
44
[view]
|
Protein-Protein |
44
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000011
Ubiquitin/SUMO-activating enzyme E1
IPR000594
UBA/THIF-type NAD/FAD binding fold
IPR009036
Molybdenum cofactor biosynthesis, MoeB
|
PFAM |
PF00899
|
PRINTS |
PR01849
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
A0AVT1
|
PhosphoSite |
PhosphoSite-A0AVT1
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
55236
|
UniGene |
Hs.743227
|
RefSeq |
|
HUGO |
HGNC:25581
|
OMIM |
611361
|
CCDS |
|
HPRD |
13341
|
IMGT |
|
EMBL |
AB014773
AC079880
AC096720
AK001670
AK094969
AK314371
AL832015
AL832458
AY359880
BC031637
BC126484
BC126486
EF623993
|
GenPept |
AAH31637
AAI26485
AAI26487
AAQ63403
AAY40999
ABR25253
BAA91824
BAB19785
BAC04463
BAG37000
CAD89908
CAD89959
|
|
|