InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLD2

Summary

InnateDB Gene

IDBG-19793.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLD2

Gene Name

phospholipase D2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000129219

Encoded Proteins

IDBP-19797

phospholipase D2

IDBP-762179

IDBP-761092

IDBP-762230

IDBP-757980

IDBP-763983

IDBP-764002

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:4807096-4823434

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000263088	ENSP00000263088
ENST00000572199
ENST00000572940	ENSP00000459571
ENST00000576983	ENSP00000460250
ENST00000573258
ENST00000575246	ENSP00000459304
ENST00000575316	ENSP00000458795
ENST00000576864	ENSP00000460477
ENST00000574796
ENST00000572127
ENST00000576329
ENST00000575813	ENSP00000461459
ENST00000574268
ENST00000575945
ENST00000571273

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004630	phospholipase D activity
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding
GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity

Biological Process

GO:0002031	G-protein coupled receptor internalization
GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006655	phosphatidylglycerol biosynthetic process
GO:0006898	receptor-mediated endocytosis
GO:0007010	cytoskeleton organization
GO:0007264	small GTPase mediated signal transduction
GO:0008152	metabolic process
GO:0016042	lipid catabolic process
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0046474	glycerophospholipid biosynthetic process