Version 5.4
Mus musculus Gene: Pld2
Summary
InnateDB Gene IDBG-194655.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pld2
Gene Name phospholipase D2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000020828
Encoded Proteins
IDBP-194657
phospholipase D2
IDBP-264276
phospholipase D2
IDBP-264278
phospholipase D2
IDBP-718883
IDBP-719011
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129219:
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70540064-70558110
Strand Forward strand
Band B3
Transcripts
ENSMUST00000018429 ENSMUSP00000018429
ENSMUST00000108557 ENSMUSP00000104197
ENSMUST00000108556 ENSMUSP00000104196
ENSMUST00000157075 ENSMUSP00000137247
ENSMUST00000130678 ENSMUSP00000136566
ENSMUST00000146248
ENSMUST00000179806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Biological Process
GO:0002031 G-protein coupled receptor internalization
GO:0006898 receptor-mediated endocytosis
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0031526 brush border membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129219
View Gene Order
ENSBTAG00000013392
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_199032
Synthesis of PG pathway
REACT_210240
Role of phospholipids in phagocytosis pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188640
Synthesis of PA pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu04912
GnRH signaling pathway pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_120906
Synthesis of PA pathway
REACT_121280
Synthesis of PG pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_6900
Immune System pathway
REACT_120870
Phospholipid metabolism pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_111217
Metabolism pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
alphasynuclein_pathway
Alpha-synuclein signaling
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
lysophospholipid_pathway
LPA receptor mediated events
erbb1_downstream_pathway
ErbB1 downstream signaling
arf_3pathway
Arf1 pathway
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.260177 Mm.398583
RefSeq NM_008876 XM_006532483 XM_006532484 XM_006537136 XM_006537137
OMIM
CCDS CCDS24953
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca