Version 5.4
Homo sapiens Gene: FYB
Summary
InnateDB Gene IDBG-17782.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FYB
Gene Name FYN binding protein
Synonyms ADAP; PRO0823; SLAP-130
Species Homo sapiens
Ensembl Gene ENSG00000082074
Encoded Proteins
IDBP-17786
FYN binding protein
IDBP-484752
FYN binding protein
IDBP-481087
FYN binding protein
IDBP-478716
FYN binding protein
IDBP-474959
FYN binding protein
IDBP-480994
FYN binding protein
IDBP-477331
FYN binding protein
IDBP-479482
FYN binding protein
IDBP-481100
FYN binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:39105236-39274528
Strand Reverse strand
Band p13.1
Transcripts
ENST00000351578 ENSP00000316460
ENST00000515010 ENSP00000426346
ENST00000512982 ENSP00000425845
ENST00000505428 ENSP00000427114
ENST00000510188 ENSP00000426597
ENST00000512138 ENSP00000424919
ENST00000506557 ENSP00000421988
ENST00000509072 ENSP00000423888
ENST00000504542 ENSP00000420989
ENST00000503065
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006607 NLS-bearing protein import into nucleus
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008150 biological_process
GO:0035556 intracellular signal transduction
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022148
View Gene Order
ENSBTAG00000001492
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_12623
Generation of second messenger molecules pathway
REACT_23916
Signal regulatory protein (SIRP) family interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_12526
TCR signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
tcr_pathway
TCR signaling in naïve CD4+ T cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370503 Hs.623715 Hs.628155
RefSeq NM_001243093 NM_001465 NM_199335 XM_006714464 XM_006714465 XM_006714466
HUGO
OMIM
CCDS CCDS47200 CCDS54848
HPRD 04107
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca