Version 5.4
Homo sapiens Gene: TARS
Summary
InnateDB Gene IDBG-14769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TARS
Gene Name threonyl-tRNA synthetase
Synonyms ThrRS
Species Homo sapiens
Ensembl Gene ENSG00000113407
Encoded Proteins
IDBP-14773
threonyl-tRNA synthetase
IDBP-363808
threonyl-tRNA synthetase
IDBP-480919
threonyl-tRNA synthetase
IDBP-481962
threonyl-tRNA synthetase
IDBP-479734
threonyl-tRNA synthetase
IDBP-483696
threonyl-tRNA synthetase
IDBP-479710
threonyl-tRNA synthetase
IDBP-483287
threonyl-tRNA synthetase
IDBP-479923
threonyl-tRNA synthetase
IDBP-475653
threonyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:33440696-33469539
Strand Forward strand
Band p13.3
Transcripts
ENST00000265112 ENSP00000265112
ENST00000455217 ENSP00000387710
ENST00000502553 ENSP00000424387
ENST00000514259 ENSP00000422130
ENST00000502508
ENST00000508361 ENSP00000427627
ENST00000507716 ENSP00000420893
ENST00000509731 ENSP00000427304
ENST00000505012 ENSP00000422291
ENST00000513066 ENSP00000425524
ENST00000506040 ENSP00000422598
ENST00000504698
ENST00000509410
ENST00000503422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 54 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004829 threonine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
GO:0042803 protein homodimerization activity
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006435 threonyl-tRNA aminoacylation
GO:0010467 gene expression
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022241
View Gene Order
ENSBTAG00000014261
Not yet available
Pathways
NETPATH
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.566377 Hs.672424
RefSeq NM_001258437 NM_001258438 NM_152295
HUGO
OMIM
CCDS CCDS3899 CCDS58943
HPRD 01762
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca