InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TARS

Summary

InnateDB Protein

IDBP-14773.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TARS

Protein Name

threonyl-tRNA synthetase

Synonyms

ThrRS;

Species

Homo sapiens

Ensembl Protein

ENSP00000265112

InnateDB Gene

IDBG-14769 (TARS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.

Experimentally validated
Total	56 [view]
Protein-Protein	54 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004829	threonine-tRNA ligase activity
GO:0005524	ATP binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds
GO:0042803	protein homodimerization activity

Biological Process

GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006435	threonyl-tRNA aminoacylation
GO:0010467	gene expression
GO:0043039	tRNA aminoacylation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
IPR002320 Threonine-tRNA ligase, class IIa
IPR004095 TGS
IPR004154 Anticodon-binding
IPR006195 Aminoacyl-tRNA synthetase, class II
IPR012676 TGS-like
IPR012947 Threonyl/alanyl tRNA synthetase, SAD
IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain

PFAM

PF00587
PF02824
PF03129
PF07973

PRINTS

PR01047

PIRSF

SMART

SM00863

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt