InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT5B

Summary

InnateDB Gene

IDBG-11885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT5B

Gene Name

wingless-type MMTV integration site family, member 5B

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000111186

Encoded Proteins

IDBP-11887

wingless-type MMTV integration site family, member 5B

IDBP-235909

wingless-type MMTV integration site family, member 5B

IDBP-585785

wingless-type MMTV integration site family, member 5B

IDBP-584711

wingless-type MMTV integration site family, member 5B

IDBP-601259

wingless-type MMTV integration site family, member 5B

IDBP-587231

wingless-type MMTV integration site family, member 5B

IDBP-595803

wingless-type MMTV integration site family, member 5B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:1529891-1647243

Strand

Forward strand

Band

p13.33

Transcripts

ENST00000310594	ENSP00000308887
ENST00000397196	ENSP00000380379
ENST00000539198	ENSP00000438414
ENST00000545811	ENSP00000445395
ENST00000537031	ENSP00000439312
ENST00000538854
ENST00000543563
ENST00000543071	ENSP00000442348
ENST00000542408	ENSP00000440600
ENST00000545747

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0007275	multicellular organismal development
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030335	positive regulation of cell migration
GO:0042060	wound healing
GO:0045165	cell fate commitment
GO:0045444	fat cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0070307	lens fiber cell development
GO:0071300	cellular response to retinoic acid
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome