Version 5.4
Homo sapiens Protein: WNT5B
Summary
InnateDB Protein IDBP-235909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT5B
Protein Name wingless-type MMTV integration site family, member 5B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380379
InnateDB Gene IDBG-11885 (WNT5B)
Protein Structure
UniProt Annotation
Function Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005109 frizzled binding
Biological Process
GO:0002062 chondrocyte differentiation
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030335 positive regulation of cell migration
GO:0042060 wound healing
GO:0045165 cell fate commitment
GO:0045444 fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0070307 lens fiber cell development
GO:0071300 cellular response to retinoic acid
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005817 Wnt
PFAM PF00110
PRINTS PR01349
PIRSF
SMART SM00097
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H1J7
PhosphoSite PhosphoSite-Q9H1J7
TrEMBL F5H7Q6
UniProt Splice Variant
Entrez Gene 81029
UniGene Hs.306051
RefSeq NP_116031
HUGO HGNC:16265
OMIM 606361
CCDS CCDS8510
HPRD 05899
IMGT
EMBL AB060966 AC004671 AC005182 AK290430 AY009399 BC001749 CH471116
GenPept AAG38659 AAH01749 BAB62039 BAF83119 EAW88925 EAW88927

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca