Version 5.4
Homo sapiens Gene: NSUN2
Summary
InnateDB Gene IDBG-11582.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSUN2
Gene Name NOP2/Sun RNA methyltransferase family, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000037474
Encoded Proteins
IDBP-11586
NOP2/Sun domain family, member 2
IDBP-479172
NOP2/Sun domain family, member 2
IDBP-476796
NOP2/Sun domain family, member 2
IDBP-480845
NOP2/Sun domain family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:6599239-6633291
Strand Reverse strand
Band p15.31
Transcripts
ENST00000264670 ENSP00000264670
ENST00000504374 ENSP00000421783
ENST00000505892
ENST00000513888
ENST00000506139 ENSP00000420957
ENST00000514127 ENSP00000426459
ENST00000502932
ENST00000507888
ENST00000505264
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 66 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0016428 tRNA (cytosine-5-)-methyltransferase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0030488 tRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005819 spindle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021595
View Gene Order
ENSBTAG00000015466
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.481526 Hs.593879 Hs.620888
RefSeq NM_001193455 NM_017755
HUGO
OMIM
CCDS CCDS3869 CCDS54832
HPRD 08620
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca