Version 5.4
Mus musculus Gene: Nsun2
Summary
InnateDB Gene IDBG-164948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nsun2
Gene Name NOL1/NOP2/Sun domain family member 2
Synonyms D13Wsu123e; Misu
Species Mus musculus
Ensembl Gene ENSMUSG00000021595
Encoded Proteins
IDBP-164950
NOL1/NOP2/Sun domain family member 2
IDBP-261838
NOL1/NOP2/Sun domain family member 2
IDBP-712319
IDBP-714999
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000037474:
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:69533746-69635780
Strand Forward strand
Band B3
Transcripts
ENSMUST00000022087 ENSMUSP00000022087
ENSMUST00000109699 ENSMUSP00000105321
ENSMUST00000143716 ENSMUSP00000134962
ENSMUST00000148115
ENSMUST00000127854
ENSMUST00000136932
ENSMUST00000136891
ENSMUST00000176485 ENSMUSP00000135455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0016428 tRNA (cytosine-5-)-methyltransferase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0030488 tRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005819 spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000037474
View Gene Order
ENSBTAG00000015466
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.260009 Mm.395981 Mm.486399
RefSeq NM_145354
OMIM
CCDS CCDS36722
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca