Version 5.4
Homo sapiens Gene: BIK
Summary
InnateDB Gene IDBG-10395.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BIK
Gene Name BCL2-interacting killer (apoptosis-inducing)
Synonyms BIP1; BP4; NBK
Species Homo sapiens
Ensembl Gene ENSG00000100290
Encoded Proteins
IDBP-10397
BCL2-interacting killer (apoptosis-inducing)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:43110748-43129712
Strand Forward strand
Band q13.2
Transcripts
ENST00000216115 ENSP00000216115
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
GO:0051400 BH domain binding
Biological Process
GO:0006915 apoptotic process
GO:0007283 spermatogenesis
GO:0008584 male gonad development
GO:0008637 apoptotic mitochondrial changes
GO:0032464 positive regulation of protein homooligomerization
GO:0090200 positive regulation of release of cytochrome c from mitochondria
Cellular Component
GO:0005740 mitochondrial envelope
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q13323
TrEMBL A0A024R4X6
UniProt Splice Variant
Entrez Gene 638
UniGene Hs.634659 Hs.739007
RefSeq NM_001197
HUGO HGNC:1051
OMIM 603392
CCDS CCDS14044
HPRD
IMGT
EMBL AF174421 AF174422 AF174423 AF174424 AL022237 AY245248 BC001599 BT006728 CH471138 CR456390 CR541863 CR541883 U34584 U49730 X89986
GenPept AAC50413 AAC79124 AAF01156 AAH01599 AAO61089 AAP35374 CAA18260 CAA62013 CAG30276 CAG46661 CAG46681 EAW73282 EAW73284
RNA Seq Atlas 638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca