InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BIK

Summary

InnateDB Protein

IDBP-10397.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BIK

Protein Name

BCL2-interacting killer (apoptosis-inducing)

Synonyms

BIP1; BP4; NBK;

Species

Homo sapiens

Ensembl Protein

ENSP00000216115

InnateDB Gene

IDBG-10395 (BIK)

Protein Structure

UniProt Annotation

Function

Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269PubMed:8521816}.

Subcellular Localization

Endomembrane system; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Around the nuclear envelope, and in cytoplasmic membranes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0051400	BH domain binding

Biological Process

GO:0006915	apoptotic process
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0008637	apoptotic mitochondrial changes
GO:0032464	positive regulation of protein homooligomerization
GO:0090200	positive regulation of release of cytochrome c from mitochondria