Bos taurus Gene: NFATC1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-643394.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | NFATC1 | ||||||||||||||||||||||
Gene Name | Nuclear factor of activated T-cells, cytoplasmic 1 | ||||||||||||||||||||||
Synonyms | NF-ATc; NF-ATc1; NFAT | ||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000000656 | ||||||||||||||||||||||
Encoded Proteins |
Nuclear factor of activated T-cells, cytoplasmic 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131196:
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2008] The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 24:1018253-1099817 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Signaling by Wnt pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
Ca2+ pathway pathway
Signal Transduction pathway
beta-catenin independent WNT signaling pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
TCR pathway
RANKL pathway
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REACTOME |
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
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KEGG |
Wnt signaling pathway pathway
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
T cell receptor signaling pathway pathway
Wnt signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
Osteoclast differentiation pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Downstream signaling in naïve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
BCR signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Cross-References | |||||||||||||||||||||||
SwissProt | P98201 | ||||||||||||||||||||||
TrEMBL | G3XCF6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 511224 | ||||||||||||||||||||||
UniGene | Bt.45162 | ||||||||||||||||||||||
RefSeq | NM_001166615 XM_005223925 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | DAAA02056013 DAAA02056014 DAAA02056015 DAAA02056016 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 511224 | ||||||||||||||||||||||