InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nfatc1

Summary

InnateDB Gene

IDBG-161489.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfatc1

Gene Name

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

Synonyms

2210017P03Rik; AI449492; AV076380; NF-ATc; NFAT2; NFATc; Nfatcb

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033016

Encoded Proteins

IDBP-161491

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-161495

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-624074

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-624077

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131196:
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2008]
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:80606205-80713071

Strand

Reverse strand

Band

Transcripts

ENSMUST00000078049	ENSMUSP00000077196
ENSMUST00000035800	ENSMUSP00000046312
ENSMUST00000170905	ENSMUSP00000129001
ENSMUST00000167977	ENSMUSP00000126884

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	9 [view]
Protein-DNA	16 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001837	epithelial to mesenchymal transition
GO:0006355	regulation of transcription, DNA-templated
GO:0006816	calcium ion transport
GO:0007507	heart development
GO:0010628	positive regulation of gene expression
GO:0030316	osteoclast differentiation
GO:0035556	intracellular signal transduction
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter