InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SREBF2

Summary

InnateDB Gene

IDBG-641973.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SREBF2

Gene Name

sterol regulatory element-binding protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014265

Encoded Proteins

IDBP-694427

sterol regulatory element binding transcription factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21408089

[Homo sapiens] SREBF2 is a key transcriptional regulator of sterol biosynthesis in lipid metabolism, and SREBP2 protein levels in macrophages are negatively regulated by type I interferon signalling during viral infection. (Demonstrated in murine model)

PMID 21408089

[Mus musculus] Srebf2 is a key transcriptional regulator of sterol biosynthesis in lipid metabolism, and Srebp2 protein levels in macrophages are negatively regulated by type I interferon signalling during viral infection.

PMID 26938778

[Mus musculus] Mir342 is involved in a novel post-transcriptional viral defence mechanism in IFN-activated macrophages by directly targeting Srebf2, Idi1, Dhcr7 and Sc4mol of the sterol pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198911:
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. [provided by RefSeq, Jul 2008]
This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:113377699-113414729

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018956

ENSBTAP00000018956

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0010886	positive regulation of cholesterol storage
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055098	response to low-density lipoprotein particle stimulus
GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:0090370	negative regulation of cholesterol efflux
GO:2000188	regulation of cholesterol homeostasis