InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Srebf2

Summary

InnateDB Gene

IDBG-166203.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srebf2

Gene Name

sterol regulatory element binding factor 2

Synonyms

AI608257; bHLHd2; lop13; nuc; SREBP-2; SREBP2; SREBP2gc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022463

Encoded Proteins

IDBP-166207

sterol regulatory element binding factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21408089

Srebf2 is a key transcriptional regulator of sterol biosynthesis in lipid metabolism, and Srebp2 protein levels in macrophages are negatively regulated by type I interferon signalling during viral infection.

PMID 26938778

Mir342 is involved in a novel post-transcriptional viral defence mechanism in IFN-activated macrophages by directly targeting Srebf2, Idi1, Dhcr7 and Sc4mol of the sterol pathway.

InnateDB Annotation from Orthologs

Summary

PMID 21408089

[Homo sapiens] SREBF2 is a key transcriptional regulator of sterol biosynthesis in lipid metabolism, and SREBP2 protein levels in macrophages are negatively regulated by type I interferon signalling during viral infection. (Demonstrated in murine model)

Entrez Gene

Summary

DISCONTINUED: This record was withdrawn by Mouse Genome Informatics (MGI).

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:82147266-82205376

Strand

Forward strand

Band

Transcripts

ENSMUST00000023100

ENSMUSP00000023100

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008203	cholesterol metabolic process
GO:0010886	positive regulation of cholesterol storage
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055098	response to low-density lipoprotein particle stimulus
GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:0090370	negative regulation of cholesterol efflux
GO:2000188	regulation of cholesterol homeostasis

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0032937	SREBP-SCAP-Insig complex