InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KDM5A

Summary

InnateDB Gene

IDBG-640967.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM5A

Gene Name

lysine-specific demethylase 5A

Synonyms

JARID1A

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020472

Encoded Proteins

IDBP-693299

lysine (K)-specific demethylase 5A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073614:
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. [provided by RefSeq, Mar 2010]
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:107730640-107791602

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000027280

ENSBTAP00000027280

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0046872	metal ion binding

Biological Process

GO:0045893	positive regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000073614

View Gene Order

ENSMUSG00000030180

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_218274

Chromatin organization pathway

REACT_256030

HDMs demethylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.107829 Bt.111498 Bt.43978

RefSeq

NM_001205625

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas