InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kdm5a

Summary

InnateDB Gene

IDBG-183502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm5a

Gene Name

lysine (K)-specific demethylase 5A

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030180

Encoded Proteins

IDBP-183504

lysine (K)-specific demethylase 5A

IDBP-183506

lysine (K)-specific demethylase 5A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073614:
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. [provided by RefSeq, Mar 2010]
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:120364099-120444574

Strand

Forward strand

Band

Transcripts

ENSMUST00000005108	ENSMUSP00000005108
ENSMUST00000100996	ENSMUSP00000098558
ENSMUST00000135802
ENSMUST00000152293
ENSMUST00000132009
ENSMUST00000124847
ENSMUST00000124525
ENSMUST00000132599
ENSMUST00000142791

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0016568	chromatin modification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000073614

View Gene Order

ENSBTAG00000020472

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_256030

HDMs demethylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.404761

RefSeq

NM_145997

OMIM

CCDS

CCDS51889

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas