InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: USP18

Summary

InnateDB Gene

IDBG-638304.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP18

Gene Name

ubl carboxyl-terminal hydrolase 18

Synonyms

bubp43

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016661

Encoded Proteins

IDBP-690380

ubl carboxyl-terminal hydrolase 18

IDBP-690383

ubl carboxyl-terminal hydrolase 18

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184979:
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:76375512-76405820

Strand

Forward strand

Band

Transcripts

ENSBTAT00000053400	ENSBTAP00000052924
ENSBTAT00000022157	ENSBTAP00000022157

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0019785	ISG15-specific protease activity
GO:0036459	ubiquitinyl hydrolase activity