Version 5.4
Mus musculus Gene: Usp18
Summary
InnateDB Gene IDBG-184385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Usp18
Gene Name ubiquitin specific peptidase 18
Synonyms 1110058H21Rik; AW047653; Ubp15; UBP43
Species Mus musculus
Ensembl Gene ENSMUSG00000030107
Encoded Proteins
IDBP-184387
ubiquitin specific peptidase 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184979:
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:121245906-121270916
Strand Forward strand
Band F1
Transcripts
ENSMUST00000032198 ENSMUSP00000032198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 2 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019785 ISG15-specific protease activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0032020 ISG15-protein conjugation
GO:0035634 response to stilbenoid
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000184979
View Gene Order
ENSBTAG00000016661
Not yet available
Pathways
NETPATH
REACTOME
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_198535
Antiviral mechanism by IFN-stimulated genes pathway
REACT_198533
ISG15 antiviral mechanism pathway
REACT_230745
Immune System pathway
REACT_198666
Interferon Signaling pathway
REACT_198627
Regulation of IFNA signaling pathway
REACT_198622
Interferon alpha/beta signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25216
Regulation of IFNA signaling pathway
REACT_25162
Interferon alpha/beta signaling pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.326911
RefSeq NM_011909
OMIM
CCDS CCDS20489
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca