Version 5.4
| Bos taurus Gene: PPIA | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-634150.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | PPIA | ||||||||
| Gene Name | Peptidyl-prolyl cis-trans isomerase A | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000012003 | ||||||||
| Encoded Proteins |
Peptidyl-prolyl cis-trans isomerase A
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] PPIA (CYPA) is a cell-intrinsic sensor for human immunodeficiency virus 1 (HIV-1) that exists in dendritic cells and mediates an antiviral innate immune response.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196262:
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 4:77409433-77413143 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
Prolactin pathway
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| REACTOME |
Basigin interactions pathway
Cell surface interactions at the vascular wall pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
APOBEC3G mediated resistance to HIV-1 infection pathway
Integration of provirus pathway
Binding and entry of HIV virion pathway
Plus-strand DNA synthesis pathway
Minus-strand DNA synthesis pathway
Uncoating of the HIV Virion pathway
Early Phase of HIV Life Cycle pathway
Late Phase of HIV Life Cycle pathway
Platelet activation, signaling and aggregation pathway
HIV Life Cycle pathway
Reverse Transcription of HIV RNA pathway
HIV Infection pathway
Assembly Of The HIV Virion pathway
Host Interactions of HIV factors pathway
Budding and maturation of HIV virion pathway
Disease pathway
Hemostasis pathway
Hemostasis pathway
Cell surface interactions at the vascular wall pathway
Basigin interactions pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | |||||||||
| RefSeq | NM_178320 XM_003583526 XM_003587373 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||