Version 5.4
Mus musculus Gene: Ppia
Summary
InnateDB Gene IDBG-147795.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppia
Gene Name peptidylprolyl isomerase A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000071866
Encoded Proteins
IDBP-540628
peptidylprolyl isomerase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20829794
[Homo sapiens] PPIA (CYPA) is a cell-intrinsic sensor for human immunodeficiency virus 1 (HIV-1) that exists in dendritic cells and mediates an antiviral innate immune response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196262:
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6415443-6419817
Strand Forward strand
Band A1
Transcripts
ENSMUST00000090749
ENSMUST00000132846 ENSMUSP00000117987
ENSMUST00000135789
ENSMUST00000137829
ENSMUST00000155824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0042277 peptide binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0045069 regulation of viral genome replication
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196262
View Gene Order
ENSBTAG00000012003
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_211508
Basigin interactions pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_56
Prolactin pathway
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_9406
APOBEC3G mediated resistance to HIV-1 infection pathway
REACT_6918
Integration of provirus pathway
REACT_6903
Binding and entry of HIV virion pathway
REACT_9037
Plus-strand DNA synthesis pathway
REACT_9055
Minus-strand DNA synthesis pathway
REACT_6965
Uncoating of the HIV Virion pathway
REACT_6266
Early Phase of HIV Life Cycle pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_6256
HIV Life Cycle pathway
REACT_6880
Reverse Transcription of HIV RNA pathway
REACT_6185
HIV Infection pathway
REACT_6818
Assembly Of The HIV Virion pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P17742
TrEMBL Q5SVY2 Q9CZK9
UniProt Splice Variant
Entrez Gene 668548
UniGene Mm.362471 Mm.400663 Mm.468823 Mm.469054 Mm.483299 Mm.5246
RefSeq NM_008907 XM_006508419 XM_006544269
OMIM
CCDS CCDS24419
HPRD
IMGT
MGI ID MGI:97749
MGI Symbol Ppia
EMBL AF171073 AK002236 AK007981 AK010649 AK012491 AK012531 AK012663 AK028210 AK131942 AK136788 AK151583 AK153030 AK160631 AK160780 AK168035 BC083076 BC087928 BC094272 BC094632 BC099478 CH466574 DQ985731 X52803
GenPept AAD50996 AAH83076 AAH87928 AAH94272 AAH94632 AAH99478 ABL77398 BAB21954 BAB25387 BAB27089 BAB28276 BAB28300 BAB28392 BAC25817 BAE20888 BAE23129 BAE30523 BAE31662 BAE35927 BAE36004 BAE40018 CAA36989 EDL40590 EDL40591
RNA Seq Atlas 268373 668548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca