Homo sapiens Gene: XRCC3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-22058.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | XRCC3 | ||||||||||||||||||||||
Gene Name | X-ray repair complementing defective repair in Chinese hamster cells 3 | ||||||||||||||||||||||
Synonyms | CMM6 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000126215 | ||||||||||||||||||||||
Encoded Proteins |
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
X-ray repair complementing defective repair in Chinese hamster cells 3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 14:103697609-103715504 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q32.33 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Homologous recombination pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Fanconi anemia pathway
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.592325 Hs.733412 | ||||||||||||||||||||||
RefSeq | NM_001100118 NM_001100119 NM_005432 XM_005268046 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS9984 | ||||||||||||||||||||||
HPRD | 07201 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||