Version 5.4
Homo sapiens Gene: HCN1
Summary
InnateDB Gene IDBG-20026.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCN1
Gene Name hyperpolarization activated cyclic nucleotide-gated potassium channel 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164588
Encoded Proteins
IDBP-20028
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:45259247-45696151
Strand Reverse strand
Band p12
Transcripts
ENST00000303230 ENSP00000307342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005222 intracellular cAMP activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0030552 cAMP binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0045176 apical protein localization
GO:0046549 retinal cone cell development
GO:0055085 transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021730
View Gene Order
ENSBTAG00000043948
Not yet available
Pathways
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_75862
HCN channels pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O60741
TrEMBL
UniProt Splice Variant
Entrez Gene 348980
UniGene Hs.353176 Hs.618126
RefSeq NM_021072 XM_006714472
HUGO HGNC:4845
OMIM 602780
CCDS CCDS3952
HPRD
IMGT
EMBL AC099514 AC114975 AC117529 AC138520 AF064876
GenPept AAC39759
RNA Seq Atlas 348980

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca