InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scarf1

Summary

InnateDB Gene

IDBG-200119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scarf1

Gene Name

scavenger receptor class F, member 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038188

Encoded Proteins

IDBP-200121

scavenger receptor class F, member 1

IDBP-400174

scavenger receptor class F, member 1

IDBP-538240

scavenger receptor class F, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19237602

[Homo sapiens] SCARF1 mediates host defence against Cryptococcus neoformans and Candida albicans through cytokine production and is required for macrophage binding to C. neoformans to control the infection in mice.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074660:
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells and mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Transcription factors ZNF444/EZF-2 and SP1 are found to be responsible for the regulation of this gene. Five alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:75513540-75526582

Strand

Forward strand

Band

Transcripts

ENSMUST00000042808	ENSMUSP00000044248
ENSMUST00000118243	ENSMUSP00000114090
ENSMUST00000123819	ENSMUSP00000120097

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion
GO:0010976	positive regulation of neuron projection development
GO:0016322	neuron remodeling
GO:0016358	dendrite development
GO:0048680	positive regulation of axon regeneration

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000074660

View Gene Order

ENSBTAG00000011483

Not yet available

Pathways

NETPATH

REACTOME

REACT_196573

Binding and Uptake of Ligands by Scavenger Receptors pathway

REACT_196603

Scavenging by Class F Receptors pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_163813

Scavenging by Class F Receptors pathway

REACT_160300

Binding and Uptake of Ligands by Scavenger Receptors pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.10486

RefSeq

NM_001004157

OMIM

CCDS

CCDS25050

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas