Version 5.4
Mus musculus Gene: Rap1gap2
Summary
InnateDB Gene IDBG-198641.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rap1gap2
Gene Name RAP1 GTPase activating protein 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000038807
Encoded Proteins
IDBP-198643
RAP1 GTPase activating protein 2
IDBP-198645
RAP1 GTPase activating protein 2
IDBP-540072
RAP1 GTPase activating protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132359:
This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:74383356-74590186
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000102521 ENSMUSP00000099580
ENSMUST00000047488 ENSMUSP00000040180
ENSMUST00000123440
ENSMUST00000145524 ENSMUSP00000117290
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0046582 Rap GTPase activator activity
Biological Process
GO:0010977 negative regulation of neuron projection development
GO:0032854 positive regulation of Rap GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0031965 nuclear membrane
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132359
View Gene Order
ENSBTAG00000020000
Not yet available
Pathways
NETPATH
REACTOME
REACT_230745
Immune System pathway
REACT_237855
Rap1 signalling pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q5SVL6
TrEMBL
UniProt Splice Variant
Entrez Gene 380711
UniGene Mm.401284 Mm.405906 Mm.425690
RefSeq XM_006533621 XM_006533624 XM_006533625 XM_006533626 XM_006533627 XM_006533628 XM_006533629 XM_006533630 XM_006533631 XM_006533632 NM_001015046 XM_006533620 XM_006533622 XM_006533623
OMIM
CCDS CCDS25032
HPRD
IMGT
MGI ID MGI:3028623
MGI Symbol Rap1gap2
EMBL AK038834 AK122424 AL604065 AL627348 AL645971 BC107388
GenPept AAI07389 BAC65706 BAE20542 CAI24516 CAI25407 CAI25645
RNA Seq Atlas 380711

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca