Version 5.4
Homo sapiens Gene: RAP1GAP2
Summary
InnateDB Gene IDBG-16537.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAP1GAP2
Gene Name RAP1 GTPase activating protein 2
Synonyms GARNL4; RAP1GA3
Species Homo sapiens
Ensembl Gene ENSG00000132359
Encoded Proteins
IDBP-16539
RAP1 GTPase activating protein 2
IDBP-361499
RAP1 GTPase activating protein 2
IDBP-589072
RAP1 GTPase activating protein 2
IDBP-589349
RAP1 GTPase activating protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:2777056-3037739
Strand Forward strand
Band p13.3
Transcripts
ENST00000254695 ENSP00000254695
ENST00000366401 ENSP00000389824
ENST00000542807 ENSP00000444890
ENST00000540393 ENSP00000439688
ENST00000575979
ENST00000574709
ENST00000571555
ENST00000574515
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0046582 Rap GTPase activator activity
Biological Process
GO:0010977 negative regulation of neuron projection development
GO:0032854 positive regulation of Rap GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0031965 nuclear membrane
GO:0043005 neuron projection
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038807
View Gene Order
ENSBTAG00000020000
Not yet available
Pathways
NETPATH
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.499659 Hs.604709 Hs.685132
RefSeq NM_001100398 NM_015085 XM_005256541 XM_005256542 XM_005256543 XM_006721477
HUGO
OMIM
CCDS CCDS45573 CCDS45574
HPRD 17028
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca