InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vamp1

Summary

InnateDB Gene

IDBG-189636.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vamp1

Gene Name

vesicle-associated membrane protein 1

Synonyms

lew; Syb-1; Syb1; VAMP-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030337

Encoded Proteins

IDBP-189638

vesicle-associated membrane protein 1

IDBP-189640

vesicle-associated membrane protein 1

IDBP-189642

vesicle-associated membrane protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139190:
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:125215551-125244543

Strand

Forward strand

Band

Transcripts

ENSMUST00000063588	ENSMUSP00000063466
ENSMUST00000032487	ENSMUSP00000032487
ENSMUST00000100942	ENSMUSP00000098503
ENSMUST00000159547
ENSMUST00000160523

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006906	vesicle fusion
GO:0007269	neurotransmitter secretion
GO:0016192	vesicle-mediated transport
GO:0017157	regulation of exocytosis
GO:0035493	SNARE complex assembly

Cellular Component

GO:0005739	mitochondrion
GO:0008021	synaptic vesicle
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031201	SNARE complex
GO:0043005	neuron projection

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000139190

View Gene Order

ENSBTAG00000014603

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04130

SNARE interactions in vesicular transport pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11184

Neurotoxicity of clostridium toxins pathway

REACT_228211

Uptake and actions of bacterial toxins pathway

REACT_200617

Toxicity of botulinum toxin type D (BoNT/D) pathway

REACT_200743

Toxicity of botulinum toxin type G (BoNT/G) pathway

REACT_116125

Disease pathway

REACT_200659

Toxicity of botulinum toxin type F (BoNT/F) pathway

KEGG

hsa04130

SNARE interactions in vesicular transport pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.270074 Mm.32321 Mm.441028

RefSeq

NM_001080557 NM_009496

OMIM

CCDS

CCDS20546 CCDS39637

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas