InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pfkl

Summary

InnateDB Gene

IDBG-168033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pfkl

Gene Name

phosphofructokinase, liver, B-type

Synonyms

AA407869; ATP-PFK; PFK-L

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020277

Encoded Proteins

IDBP-168035

phosphofructokinase, liver, B-type

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141959:
Phosphofructokinase (PFK) is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate. Separate genes encode a muscle subunit (M) and a liver subunit (L). PFK from muscle is a homotetramer of M subunits, PFK from liver is a homotetramer of L-subunits, while PFK from platelets can be composed of any tetrameric combination of M and L subunits. The protein encoded by this gene represents the L subunit. Alternate splicing results in two transcript variants, one of which is a candidate for nonsense-mediated decay (NMD). [provided by RefSeq, Aug 2008]
This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:77986947-78010083

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020522	ENSMUSP00000020522
ENSMUST00000149271
ENSMUST00000148818
ENSMUST00000145716

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003872	6-phosphofructokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048029	monosaccharide binding
GO:0070061	fructose binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006096	glycolytic process
GO:0009749	response to glucose
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0046676	negative regulation of insulin secretion
GO:0046835	carbohydrate phosphorylation
GO:0051259	protein oligomerization
GO:0051289	protein homotetramerization