Version 5.4
| Mus musculus Gene: Tdp1 | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Gene | IDBG-163560.6 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | Tdp1 | ||||||||||||||
| Gene Name | tyrosyl-DNA phosphodiesterase 1 | ||||||||||||||
| Synonyms | 2810481F14Rik; 4921509N21Rik; AI838772; AW493413; E430034L06Rik; MLZ-501; SCAN1 | ||||||||||||||
| Species | Mus musculus | ||||||||||||||
| Ensembl Gene | ENSMUSG00000021177 | ||||||||||||||
| Encoded Proteins |
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase 1
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| Protein Structure | |||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
| Entrez Gene | |||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000042088:
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||
| Type | Protein coding | ||||||||||||||
| Genomic Location | Chromosome 12:99884517-99955219 | ||||||||||||||
| Strand | Forward strand | ||||||||||||||
| Band | E | ||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
Processing of DNA ends prior to end rejoining pathway
Nonhomologous End-joining (NHEJ) pathway
Double-Strand Break Repair pathway
DNA Repair pathway
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| KEGG | |||||||||||||||
| INOH | |||||||||||||||
| PID NCI | |||||||||||||||
| Cross-References | |||||||||||||||
| SwissProt | |||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | |||||||||||||||
| UniGene | Mm.312323 | ||||||||||||||
| RefSeq | NM_028354 XM_006515365 | ||||||||||||||
| OMIM | |||||||||||||||
| CCDS | CCDS26105 | ||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| MGI ID | |||||||||||||||
| MGI Symbol | |||||||||||||||
| EMBL | |||||||||||||||
| GenPept | |||||||||||||||
| RNA Seq Atlas | |||||||||||||||