InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Npy

Summary

InnateDB Gene

IDBG-146626.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npy

Gene Name

neuropeptide Y

Synonyms

0710005A05Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029819

Encoded Proteins

IDBP-146628

neuropeptide Y

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122585:
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:49822710-49829507

Strand

Forward strand

Band

B2.3

Transcripts

ENSMUST00000031843

ENSMUSP00000031843

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005179	hormone activity

Biological Process

GO:0007218	neuropeptide signaling pathway
GO:0008217	regulation of blood pressure
GO:0008343	adult feeding behavior
GO:0021954	central nervous system neuron development
GO:0021987	cerebral cortex development
GO:0031175	neuron projection development
GO:0032100	positive regulation of appetite