InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCF3

Summary

InnateDB Protein

IDBP-809040.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCF3

Protein Name

transcription factor 3

Synonyms

bHLHb21; E2A; E47; ITF1; TCF-3; VDIR;

Species

Homo sapiens

Ensembl Protein

ENSP00000480564

InnateDB Gene

IDBG-14881 (TCF3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	188 [view]
Protein-Protein	181 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0035326	enhancer binding
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070491	repressing transcription factor binding
GO:0070644	vitamin D response element binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002326	B cell lineage commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030183	B cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0033152	immunoglobulin V(D)J recombination
GO:0042692	muscle cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045787	positive regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051149	positive regulation of muscle cell differentiation
GO:2000045	regulation of G1/S transition of mitotic cell cycle