Homo sapiens Protein: YES1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-726465.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | YES1 | ||||||||||||||||||||||
Protein Name | |||||||||||||||||||||||
Synonyms | c-yes; HsT441; P61-YES; Yes; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000462468 | ||||||||||||||||||||||
InnateDB Gene | IDBG-363 (YES1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. {ECO:0000269PubMed:11901164, ECO:0000269PubMed:18479465, ECO:0000269PubMed:19276087, ECO:0000269PubMed:21566460, ECO:0000269PubMed:21713032}. | ||||||||||||||||||||||
Subcellular Localization | Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. {ECO:0000269PubMed:2021534, ECO:0000269PubMed:2067846}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR000980 SH2 domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001452 SH3 domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR011511 Variant SH3 domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF00017 PF14633 PF07714 PF00018 PF14604 PF07653 |
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PRINTS |
PR00401
PR00109 PR00452 |
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PIRSF | |||||||||||||||||||||||
SMART |
SM00252
SM00326 SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P07947 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P07947 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 7525 | ||||||||||||||||||||||
UniGene | Hs.714213 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
HUGO | HGNC:12841 | ||||||||||||||||||||||
OMIM | 164880 | ||||||||||||||||||||||
CCDS | CCDS11824 | ||||||||||||||||||||||
HPRD | 01285 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AP001178 BC048960 CH471113 M15990 | ||||||||||||||||||||||
GenPept | AAA35735 AAH48960 EAX01709 EAX01710 | ||||||||||||||||||||||